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Understanding Proteome Biology in Cardiovascular Medicine
Our research program focuses on developing integrative omics and data science approaches to elucidate the mechanisms underlying cardiac phenotypes. This involves employing analytical and computational methods to interrogate how protein dynamics orchestrate higher physiological functions in normal and diseased hearts. Since our launch in 1992, this research program has authored 163 manuscripts in cardiovascular medicine, omics phenotyping, and clinical informatics. We utilize cutting-edge proteomics and biochemistry methods to understand the regulatory relationships between protein expression level and temporal dynamics, organelle functions, and cardiac phenotypes. We have optimized proteomics technologies to expand protein parameters observed on a large scale, including quantification of proteome-wide post-translational modifications, localizations, and temporal dynamics to detect previously undiscovered disease signatures. Dr. Peipei Ping, the director of our research program, is strongly committed to supporting and mentoring the future generation of data-based biomedical researchers. She summarizes our mission as follows: “To provide an environment for students, fellows, and colleagues for creative work, and to remind everyone to share and enjoy the roses in life”.
NIH BD2K Center of Excellence @ UCLA (HeartBD2K)
A Community Effort to Translate Protein Data to Knowledge: An Integrated Platform